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Santorini island, Cyclades, Greek: the collapsed caldera seen from Oia village. Santorini is an island located in the southern Aegean Sea, about 200 km southeast from Greece's mainland. It is the largest island of a small, circular archipelago which bears the same name and is the remnant of a volcanic caldera. It forms the southernmost member of the Cyclades group of islands, with an area of approximately 73 kmq.