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Free with trial Crystal Structure of Circadian Clock Protein KaiC at 2. 8 A resolution. KaiC is an essential circadian protein in cyanobacteria. The structure resembles a double doughnut with a central pore that is partially sealed at one end. The crystal structure reveals ATP binding, inter-subunit organization, a scaffold for Kai-protein complex formation, the location of critical KaiC mutations, and evolutionary relationships to other proteins. A key auto-phosphorylation site on KaiC (T432) is identified from the crystal structure, and mutation of this residue abolishes circadian rhythmicity. The crystal structure of KaiC will be essential for understanding this circadian clockwork and for establishing its links to global gene expression. Cellular mutation illustrations Protein. Crystal Structure of Circadian Clock Protein KaiC at 2.8 A resolution. KaiC is an essential circadian protein in cyanobacteria. The structure resembles. Crystal Structure of Circadian Clock Protein KaiC at 2.8 A resolution. KaiC is an essential circadian protein in cyanobacteria. The structure resembles a double doughnut with a central pore that is partially sealed at one end. The crystal structure reveals ATP binding, inter-subunit organization, a scaffold for Kai-protein complex formation, the location of critical KaiC mutations, and evolutionary relationships to other proteins. A key auto-phosphorylation site on KaiC (T432) is identified from the crystal structure, and mutation of this residue abolishes circadian rhythmicity. The crystal structure of KaiC will be essential for understanding this circadian clockwork and for establishing its links to global gene expression.
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Free with trial P53 prevents cancer formation and acts as a guardian of the genome. Mutations in the p53 gene contribute to about half of the cases of human cancer. Cellular mutation illustrations P53 tumor suppressor bound to DNA. P53 prevents cancer formation and acts as a guardian of the genome. Mutations in the p53 gene contribute to about half of the. P53 prevents cancer formation and acts as a guardian of the genome. Mutations in the p53 gene contribute to about half of the cases of human cancer.
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